Antibiotics and Anthrax

Anthrax is readily susceptible to numerous antibiotics. Table 1 is a list of antibiotics that have shown activity against anthrax. The antibiotics in bold print are those most referenced for treatment of anthrax. Penicillin G has long been the drug of choice used for the treatment of anthrax. A treatment regimen of penicillin G of 2 million units given intravenously every two hours is recommended for the treatment of inhalation anthrax. The US military favours the use of a drug combination of 400 mg of ciprofloxacin given intravenously every eight to twelve hours, given with an initial dose of 200 mg of doxycycline intravenously, followed by a dose of 100 mg of doxycycline intravenously every eight to twelve hours.

Table 1 Antibiotics with Activity versus Anthrax
aureomycin immune
cefazolin serum
cephalothin methicillin
chloramphenical nafcillin
chloromycetin oxacillin
ciprofloxacin penicillin G
clindamycin sulfadiazine
doxycycline terramycin
erythromycin tetracycline
gentamicin vancomycin

Antibiotics and Anthrax



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